Dişi sıçanlarda Resveratrol'ün Metotreksat ile indüklenen renal toksisiteye karşı nefroprotektif etkisi

The study purposed to appraise the nephroprotective effects of resveratrol-(RES) in relation methotrexate-(MTX)-induced renal toxicity female rats. animals were allocated into three groups with six each group: control, MTX:(15 mg/kg, only a dose, i.p), MTX+RES (15 mg/kg MTX, i.p + 20 RES, dose daily, oral gavage, 7 days). efficacy was interpreted by measuring biochemical parameters such as serum function markers (uric acid, BUN and creatinine), total oxidant (TOS) antioxidant status (TAS) homogenates. Moreover, effect RES on kidneys appraised histopathological immunohistochemical analyzes. In MTX-induced rats, treatment exhibited its significant increase TAS well decrease TOS levels. parallel data, it observed that had protective histological staining findings. Immunohistochemically, determined TNF-α, one indicators systemic inflammatory response, decreased RES-treatment. findings show administration 1 hour before MTX injection rats has curative damage.